A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Excitatory neurons are preferentially impaired in early Alzheimer’s disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to inhibitory neurons, not only...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Neurosci
Hlavní autoři: Fu, Hongjun, Possenti, Andrea, Freer, Rosie, Nakano, Yoshikazu, Hernandez Villegas, Nancy C., Tang, Maoping, Cauhy, Paula V. M, Lassus, Benjamin A., Chen, Shuo, Fowler, Stephanie L., Figueroa, Helen Y., Huey, Edward D., Johnson, Gail V.W., Vendruscolo, Michele, Duff, Karen E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330709/
https://ncbi.nlm.nih.gov/pubmed/30559469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0298-7
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky