3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

3D volume imaging using iDISCO+ was applied to observe the spatial and temporal progression of tau pathology in deep structures of the brain of a mouse model that recapitulates the earliest stages of Alzheimer’s disease (AD). Tau pathology was compared at four timepoints, up to 34 months as it sprea...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fu, Hongjun, Hussaini, S. Abid, Wegmann, Susanne, Profaci, Caterina, Daniels, Jacob D., Herman, Mathieu, Emrani, Sheina, Figueroa, Helen Y., Hyman, Bradley T., Davies, Peter, Duff, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965059/
https://ncbi.nlm.nih.gov/pubmed/27466814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159463
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