Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We first tested whether SYNJ1 contributes to phenotypic variations in familial Alzheimer’s disease (FAD) and show that SYNJ1 polymorphisms are associated with age of onset in both early- and late-onset h...

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Publicat a:Cell Rep
Autors principals: Miranda, Andre M., Herman, Mathieu, Cheng, Rong, Nahmani, Eden, Barrett, Geoffrey, Micevska, Elizabeta, Fontaine, Gaelle, Potier, Marie-Claude, Head, Elizabeth, Schmitt, Frederick A., Lott, Ira T., Jiménez-Velázquez, Ivonne Z., Antonarakis, Stylianos E., Paolo, Gilbert Di, Lee, Joseph H., Hussaini, S. Abid, Marquer, Catherine
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040810/
https://ncbi.nlm.nih.gov/pubmed/29874583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.011
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