Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These endosome abnormalities have been implicated in the early development of Alzheimer's disease (AD) pathology in these subjects. Here, we show the presence of enlarged endosomes in blood mononuclear...

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Main Authors: Cossec, Jack-Christophe, Lavaur, Jérémie, Berman, Diego E., Rivals, Isabelle, Hoischen, Alexander, Stora, Samantha, Ripoll, Clémentine, Mircher, Clotilde, Grattau, Yann, OlivoMarin, Jean-Christophe, de Chaumont, Fabrice, Lecourtois, Magalie, Antonarakis, Stylianos E., Veltman, Joris A., Delabar, Jean M., Duyckaerts, Charles, Di Paolo, Gilbert, Potier, Marie-Claude
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384382/
https://ncbi.nlm.nih.gov/pubmed/22511594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds142
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