Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These endosome abnormalities have been implicated in the early development of Alzheimer's disease (AD) pathology in these subjects. Here, we show the presence of enlarged endosomes in blood mononuclear...

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Autors principals: Cossec, Jack-Christophe, Lavaur, Jérémie, Berman, Diego E., Rivals, Isabelle, Hoischen, Alexander, Stora, Samantha, Ripoll, Clémentine, Mircher, Clotilde, Grattau, Yann, OlivoMarin, Jean-Christophe, de Chaumont, Fabrice, Lecourtois, Magalie, Antonarakis, Stylianos E., Veltman, Joris A., Delabar, Jean M., Duyckaerts, Charles, Di Paolo, Gilbert, Potier, Marie-Claude
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384382/
https://ncbi.nlm.nih.gov/pubmed/22511594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds142
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