Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer’s Disease

The phosphoinositide phosphatase synaptojanin 1 (SYNJ1) is a key regulator of synaptic function. We first tested whether SYNJ1 contributes to phenotypic variations in familial Alzheimer’s disease (FAD) and show that SYNJ1 polymorphisms are associated with age of onset in both early- and late-onset h...

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Vydáno v:Cell Rep
Hlavní autoři: Miranda, Andre M., Herman, Mathieu, Cheng, Rong, Nahmani, Eden, Barrett, Geoffrey, Micevska, Elizabeta, Fontaine, Gaelle, Potier, Marie-Claude, Head, Elizabeth, Schmitt, Frederick A., Lott, Ira T., Jiménez-Velázquez, Ivonne Z., Antonarakis, Stylianos E., Paolo, Gilbert Di, Lee, Joseph H., Hussaini, S. Abid, Marquer, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040810/
https://ncbi.nlm.nih.gov/pubmed/29874583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.011
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