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Dementia in Down syndrome: unique insights for Alzheimer disease research
Virtually all adults with Down syndrome (DS) show neuropathological changes of Alzheimer disease (AD) by age 40 years. This association is due partially to overexpression of amyloid precursor protein, encoded by APP, owing to the location of this gene on chromosome 21. Amyloid-β (Aβ) accumulates in...
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| Veröffentlicht in: | Nat Rev Neurol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8061428/ https://ncbi.nlm.nih.gov/pubmed/30733618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41582-018-0132-6 |
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