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Aging in Down syndrome and the Development of Alzheimer's disease Neuropathology

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The overexpression of the gene for the amyloid precursor protein (APP), on chromosome 21, leads to early onset beta-amyloid (Aβ) plaques in DS. In add...

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Detalhes bibliográficos
Publicado no:Curr Alzheimer Res
Main Authors: Head, Elizabeth, Lott, Ira T., Wilcock, Donna M., Lemere, Cynthia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948181/
https://ncbi.nlm.nih.gov/pubmed/26651341
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