Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

Increasing evidence is implicating mitochondrial dysfunction as a central factor in the etiology of Alzheimer's disease (AD). The most significant risk factor in AD is advanced age and an important neuropathological correlate of AD is the deposition of amyloid-β peptide (Aβ(40) and Aβ(42)) in t...

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Detalhes bibliográficos
Main Authors: Coskun, Pinar E., Wyrembak, Joanne, Derbereva, Olga, Melkonian, Goar, Doran, Eric, Lott, Ira T., Head, Elizabeth, Cotman, Carl W., Wallace, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175722/
https://ncbi.nlm.nih.gov/pubmed/20463402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100351
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