Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer disease

Adults with Down syndrome (DS) develop Alzheimer’s disease (AD) neuropathology by 40 years of age. Synaptophysin (SYN) consistently declines with age and is further reduced with sporadic AD. Thus, we hypothesized that SYN would be reduced in DS with AD. The gene for synaptojanin-1 (SYNJ1), involved...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Martin, Sarah B., Dowling, Amy L.S., Lianekhammy, Joann, Lott, Ira T., Doran, Eric, Murphy, M. Paul, Beckett, Tina L., Schmitt, Frederick A., Head, Elizabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392817/
https://ncbi.nlm.nih.gov/pubmed/24927707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-140795
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