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Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer disease
Adults with Down syndrome (DS) develop Alzheimer’s disease (AD) neuropathology by 40 years of age. Synaptophysin (SYN) consistently declines with age and is further reduced with sporadic AD. Thus, we hypothesized that SYN would be reduced in DS with AD. The gene for synaptojanin-1 (SYNJ1), involved...
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| Udgivet i: | J Alzheimers Dis |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4392817/ https://ncbi.nlm.nih.gov/pubmed/24927707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-140795 |
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