Down syndrome: Age-dependence of PiB binding in postmortem frontal cortex across the lifespan

Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh Compound B (PiB) ligand has facilitated studies linking Aβ, c...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: LeVine, Harry, Spielmann, H. Peter, Matveev, Sergey, Cauvi, Francesca Macchiavello, Murphy, M. Paul, Beckett, Tina L., McCarty, Katie, Lott, Ira T., Doran, Eric, Schmitt, Frederick, Head, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638297/
https://ncbi.nlm.nih.gov/pubmed/28385551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.03.005
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