Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer disease

Adults with Down syndrome (DS) develop Alzheimer’s disease (AD) neuropathology by 40 years of age. Synaptophysin (SYN) consistently declines with age and is further reduced with sporadic AD. Thus, we hypothesized that SYN would be reduced in DS with AD. The gene for synaptojanin-1 (SYNJ1), involved...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Martin, Sarah B., Dowling, Amy L.S., Lianekhammy, Joann, Lott, Ira T., Doran, Eric, Murphy, M. Paul, Beckett, Tina L., Schmitt, Frederick A., Head, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392817/
https://ncbi.nlm.nih.gov/pubmed/24927707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-140795
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