Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that tau spreads through defined synaptic circuits, it is currently un...

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Detaylı Bibliyografya
Yayımlandı:Synapse
Asıl Yazarlar: Pickett, Eleanor K., Henstridge, Christopher M., Allison, Elizabeth, Pitstick, Rose, Pooler, Amy, Wegmann, Susanne, Carlson, George, Hyman, Bradley T., Spires‐Jones, Tara L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516127/
https://ncbi.nlm.nih.gov/pubmed/28196395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.21965
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