Tau - amyloid interactions in the rTgTauEC model of early Alzheimer’s disease suggest amyloid induced disruption of axonal projections and exacerbated axonal pathology

Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer’s disease suggested a hierarchical vulnerability of neurons for tangles, and a widespread nonspecific pattern of plaques that nonetheless seemed to correlate with the terminal zone of tangle bearing neuron...

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Main Authors: Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne K, Pitstick, Rose, Kay, Kevin R, Sanchez, Laura, Carlson, George A, Gomez-Isla, Teresa, Albers, Mark W, Spires-Jones, Tara L, Hyman, Bradley T
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797265/
https://ncbi.nlm.nih.gov/pubmed/23839581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23411
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