Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

INTRODUCTION: In early stages of Alzheimer’s disease (AD), neurofibrillary tangles (NFT) are largely restricted to the entorhinal cortex and medial temporal lobe. At later stages, when clinical symptoms generally occur, NFT involve widespread limbic and association cortices. At this point in the dis...

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Bibliografski detalji
Izdano u:Acta Neuropathol Commun
Glavni autori: Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose, Beier, David R, Carlson, George A, Spires-Jones, Tara L, Hyman, Bradley T
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371800/
https://ncbi.nlm.nih.gov/pubmed/25853174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0199-x
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