Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

In Alzheimer's disease and tauopathies, tau protein aggregates into neurofibrillary tangles that progressively spread to synaptically connected brain regions. A prion‐like mechanism has been suggested: misfolded tau propagating through the brain seeds neurotoxic aggregation of soluble tau in re...

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Foilsithe in:EMBO J
Main Authors: Wegmann, Susanne, Maury, Eduardo A, Kirk, Molly J, Saqran, Lubna, Roe, Allyson, DeVos, Sarah L, Nicholls, Samantha, Fan, Zhanyun, Takeda, Shuko, Cagsal‐Getkin, Ozge, William, Christopher M, Spires‐Jones, Tara L, Pitstick, Rose, Carlson, George A, Pooler, Amy M, Hyman, Bradley T
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2015
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687785/
https://ncbi.nlm.nih.gov/pubmed/26538322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592748
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