The intersection of amyloid beta and tau at synapses in Alzheimer’s disease

Por Spires-Jones, Tara L, Hyman, Bradley T
Publicado em 2014

Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

Por Rozkalne, Anete, Hyman, Bradley T, Spires-Jones, Tara L
Publicado em 2010

Alzheimer's disease: synapses gone cold

Por Koffie, Robert M, Hyman, Bradley T, Spires-Jones, Tara L
Publicado em 2011

Soluble forms of tau are toxic in Alzheimer’s disease

Por Kopeikina, Katherine J, Hyman, Bradley T, Spires-Jones, Tara L
Publicado em 2012

Interactions of pathological proteins in neurodegenerative diseases

Por Spires-Jones, Tara L., Attems, Johannes, Thal, Dietmar Rudolf
Publicado no Acta Neuropathol (2017)

A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer’s disease mouse model

Por Rozkalne, Anete, Spires-Jones, Tara L, Stern, Edward A, Hyman, Bradley T
Publicado em 2009

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

Por de Calignon, Alix, Spires-Jones, Tara L., Pitstick, Rose, Carlson, George A., Hyman, Bradley T.
Publicado em 2009

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer’s disease

Por Crimins, Johanna L., Pooler, Amy, Polydoro, Manuela, Luebke, Jennifer I., Spires-Jones, Tara L.
Publicado em 2013

Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

Por Spires-Jones, Tara L, Kay, Kevin, Matsouka, Roland, Rozkalne, Anete, Betensky, Rebecca A, Hyman, Bradley T
Publicado em 2010

Monitoring protein aggregation and toxicity in Alzheimer’s disease mouse models using in vivo imaging

Por Spires-Jones, Tara L, de Calignon, Alix, Meyer-Luehmann, Melanie, Bacskai, Brian J, Hyman, Bradley T
Publicado em 2010

Are Tangles as Toxic as They Look?

Por Spires-Jones, Tara L., Kopeikina, Katherine J., Koffie, Robert M., de Calignon, Alix, Hyman, Bradley T.
Publicado em 2011

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

Por Takeda, Shuko, Hashimoto, Tadafumi, Roe, Allyson D., Hori, Yukiko, Spires-Jones, Tara L., Hyman, Bradley T.
Publicado em 2013

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

Por Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Publicado em 2013

A Reporter of Local Dendritic Translocation Shows Plaque- Related Loss of Neural System Function in APP-Transgenic Mice

Por Meyer-Luehmann, Melanie, Mielke, Matthew, Spires-Jones, Tara L., Stoothoff, Will, Jones, Phill, Bacskai, Brian J., Hyman, Bradley T.
Publicado em 2009

Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

Por Koffie, Robert M., Farrar, Christian T., Saidi, Laiq-Jan, William, Christopher M., Hyman, Bradley T., Spires-Jones, Tara L.
Publicado em 2011

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

Por Spires-Jones, Tara L., Fox, Leora M., Rozkalne, Anete, Pitstick, Rose, Carlson, George A., Kazantsev, Aleksey G.
Publicado em 2012

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

Por Tai, Hwan-Ching, Serrano-Pozo, Alberto, Hashimoto, Tadafumi, Frosch, Matthew P., Spires-Jones, Tara L., Hyman, Bradley T.
Publicado em 2012

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

Por Spires-Jones, Tara L, Friedman, Taylor, Pitstick, Rose, Polydoro, Manuela, Roe, Allyson, Carlson, George A, Hyman, Bradley T
Publicado em 2014

Orchestrated experience-driven Arc/Arg3.1 responses are disrupted in a mouse model of Alzheimer’s disease

Por Rudinskiy, Nikita, Hawkes, Jonathan M., Betensky, Rebecca A., Eguchi, Megumi, Yamaguchi, Shun, Spires-Jones, Tara L., Hyman, Bradley T.
Publicado em 2012

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

Por Tai, Hwan-Ching, Wang, Bo Y, Serrano-Pozo, Alberto, Frosch, Matthew P, Spires-Jones, Tara L, Hyman, Bradley T
Publicado em 2014