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Soluble forms of tau are toxic in Alzheimer’s disease

Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau, is a hallmark of Alzheimer Disease. NFT have been considered causative of neuronal death, however, recent evidence challenges this idea. Other species of tau, such as soluble misfolded, hyperphosphoryl...

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Autors principals: Kopeikina, Katherine J, Hyman, Bradley T, Spires-Jones, Tara L
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460520/
https://ncbi.nlm.nih.gov/pubmed/23029602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s13380-012-0032-y
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