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Soluble forms of tau are toxic in Alzheimer’s disease

Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau, is a hallmark of Alzheimer Disease. NFT have been considered causative of neuronal death, however, recent evidence challenges this idea. Other species of tau, such as soluble misfolded, hyperphosphoryl...

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Hlavní autoři: Kopeikina, Katherine J, Hyman, Bradley T, Spires-Jones, Tara L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460520/
https://ncbi.nlm.nih.gov/pubmed/23029602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s13380-012-0032-y
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