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Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

There is a growing body of evidence that soluble oligomeric forms of amyloid β (Aβ) play a critical role in Alzheimer's disease (AD). Despite the importance of soluble Aβ oligomers as a therapeutic target for AD, the dynamic metabolism of these Aβ species in vivo has not been elucidated because...

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Detalhes bibliográficos
Main Authors: Takeda, Shuko, Hashimoto, Tadafumi, Roe, Allyson D., Hori, Yukiko, Spires-Jones, Tara L., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714573/
https://ncbi.nlm.nih.gov/pubmed/23640054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-229666
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