Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide

Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder causing dementia. Massive deposition of amyloid β peptide (Aβ) as senile plaques in the brain is the pathological hallmark of AD, but oligomeric, soluble forms of Aβ have been implicated as the synaptotoxic compo...

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Detalhes bibliográficos
Main Authors: Hashimoto, Tadafumi, Serrano-Pozo, Alberto, Hori, Yukiko, Adams, Kenneth W., Takeda, Shuko, Banerji, Adrian Olaf, Mitani, Akinori, Joyner, Daniel, Thyssen, Diana H., Bacskai, Brian J., Frosch, Matthew P., Spires-Jones, Tara L., Finn, Mary Beth, Holtzman, David M., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493562/
https://ncbi.nlm.nih.gov/pubmed/23100439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1542-12.2012
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