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Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

Calcineurin has been implicated as part of a critical signaling pathway for learning and memory, and recent data suggest that calcineurin activation mediates some of the neurotoxicity of the Alzheimer related neurotoxin Aβ. Immunosuppression via calcineurin inhibition with the compound FK506 is an i...

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Detalhes bibliográficos
Main Authors: Spires-Jones, Tara L, Kay, Kevin, Matsouka, Roland, Rozkalne, Anete, Betensky, Rebecca A, Hyman, Bradley T
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010509/
https://ncbi.nlm.nih.gov/pubmed/20970476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.10.033
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