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Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain

Calcineurin has been implicated as part of a critical signaling pathway for learning and memory, and recent data suggest that calcineurin activation mediates some of the neurotoxicity of the Alzheimer related neurotoxin Aβ. Immunosuppression via calcineurin inhibition with the compound FK506 is an i...

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Bibliografische gegevens
Hoofdauteurs: Spires-Jones, Tara L, Kay, Kevin, Matsouka, Roland, Rozkalne, Anete, Betensky, Rebecca A, Hyman, Bradley T
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010509/
https://ncbi.nlm.nih.gov/pubmed/20970476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.10.033
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