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Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) (1, 2). Progression of NFT pathology is closely correlated with both increased neurodegeneration and cogni...

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Detalhes bibliográficos
Main Authors: Kuchibhotla, Kishore V., Wegmann, Susanne, Kopeikina, Katherine J., Hawkes, Jonathan, Rudinskiy, Nikita, Andermann, Mark L., Spires-Jones, Tara L., Bacskai, Brian J., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890777/
https://ncbi.nlm.nih.gov/pubmed/24368848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318807111
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