Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein. Its “repeat domain” (TauRD) is mainly responsible for the aggregation properties, and oligomeric forms are thought to dominate the toxic effects of Tau. Here we investigated th...

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Hlavní autoři: Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106345/
https://ncbi.nlm.nih.gov/pubmed/24825901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554725
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