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Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein. Its “repeat domain” (TauRD) is mainly responsible for the aggregation properties, and oligomeric forms are thought to dominate the toxic effects of Tau. Here we investigated th...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4106345/ https://ncbi.nlm.nih.gov/pubmed/24825901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554725 |
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