Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein. Its “repeat domain” (TauRD) is mainly responsible for the aggregation properties, and oligomeric forms are thought to dominate the toxic effects of Tau. Here we investigated th...

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Detalhes bibliográficos
Main Authors: Kumar, Satish, Tepper, Katharina, Kaniyappan, Senthilvelrajan, Biernat, Jacek, Wegmann, Susanne, Mandelkow, Eva-Maria, Müller, Daniel J., Mandelkow, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106345/
https://ncbi.nlm.nih.gov/pubmed/24825901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554725
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