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Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability
Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We applied high resolution atomic force and EM microscopy to study fibrils assembled from different human Tau isoforms and domains. All fibrils reveal structural polymorphism; the “thin twisted” and “thin smooth” fib...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930729/ https://ncbi.nlm.nih.gov/pubmed/20566652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145318 |
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