Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We applied high resolution atomic force and EM microscopy to study fibrils assembled from different human Tau isoforms and domains. All fibrils reveal structural polymorphism; the “thin twisted” and “thin smooth” fib...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wegmann, Susanne, Jung, Yu Jin, Chinnathambi, Subashchandrabose, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Muller, Daniel J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930729/
https://ncbi.nlm.nih.gov/pubmed/20566652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145318
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