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Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We applied high resolution atomic force and EM microscopy to study fibrils assembled from different human Tau isoforms and domains. All fibrils reveal structural polymorphism; the “thin twisted” and “thin smooth” fib...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wegmann, Susanne, Jung, Yu Jin, Chinnathambi, Subashchandrabose, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Muller, Daniel J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930729/
https://ncbi.nlm.nih.gov/pubmed/20566652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145318
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