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The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

The structure and properties of amyloid-like Tau fibrils accumulating in neurodegenerative diseases have been debated for decades. Although the core of Tau fibrils assembles from short β-strands, the properties of the much longer unstructured Tau domains protruding from the fibril core remain largel...

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Bibliografiske detaljer
Main Authors: Wegmann, Susanne, Medalsy, Izhar D., Mandelkow, Eckhard, Müller, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557036/
https://ncbi.nlm.nih.gov/pubmed/23269837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212100110
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