Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

Slow oscillations are important for consolidation of memory during sleep, and Alzheimer’s disease (AD) patients experience memory disturbances. Thus, we examined slow oscillation activity in an animal model of AD. APP mice exhibit aberrant slow oscillation activity. Aberrant inhibitory activity with...

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Udgivet i:PLoS One
Main Authors: Kastanenka, Ksenia V., Hou, Steven S., Shakerdge, Naomi, Logan, Robert, Feng, Danielle, Wegmann, Susanne, Chopra, Vanita, Hawkes, Jonathan M., Chen, Xiqun, Bacskai, Brian J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257003/
https://ncbi.nlm.nih.gov/pubmed/28114405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170275
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