Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

BACKGROUND: Abnormal accumulation of amyloid β(1–42) oligomers (AβO(1–42)), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positive (...

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Xehetasun bibliografikoak
Argitaratua izan da:BMC Biol
Egile Nagusiak: Park, Kyerl, Lee, Jaedong, Jang, Hyun Jae, Richards, Blake A., Kohl, Michael M., Kwag, Jeehyun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961381/
https://ncbi.nlm.nih.gov/pubmed/31937327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-019-0732-7
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