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Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer’s disease. However, the underlying neuronal mechanisms are unknown. By employing in vivo two-photon Ca(2+) imaging of layer 2/3 cortical ne...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Busche, Marc Aurel, Wegmann, Susanne, Dujardin, Simon, Commins, Caitlin, Schiantarelli, Julia, Klickstein, Naomi, Kamath, Tarun V., Carlson, George A., Nelken, Israel, Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560629/
https://ncbi.nlm.nih.gov/pubmed/30559471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0289-8
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