Tau protein liquid–liquid phase separation can initiate tau aggregation

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under cellular conditions and that phase‐separated tau...

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書誌詳細
出版年:EMBO J
主要な著者: Wegmann, Susanne, Eftekharzadeh, Bahareh, Tepper, Katharina, Zoltowska, Katarzyna M, Bennett, Rachel E, Dujardin, Simon, Laskowski, Pawel R, MacKenzie, Danny, Kamath, Tarun, Commins, Caitlin, Vanderburg, Charles, Roe, Allyson D, Fan, Zhanyun, Molliex, Amandine M, Hernandez‐Vega, Amayra, Muller, Daniel, Hyman, Anthony A, Mandelkow, Eckhard, Taylor, J Paul, Hyman, Bradley T
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2018
主題:
Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881631/
https://ncbi.nlm.nih.gov/pubmed/29472250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798049
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