Tau protein liquid–liquid phase separation can initiate tau aggregation

The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under cellular conditions and that phase‐separated tau...

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Vydáno v:EMBO J
Hlavní autoři: Wegmann, Susanne, Eftekharzadeh, Bahareh, Tepper, Katharina, Zoltowska, Katarzyna M, Bennett, Rachel E, Dujardin, Simon, Laskowski, Pawel R, MacKenzie, Danny, Kamath, Tarun, Commins, Caitlin, Vanderburg, Charles, Roe, Allyson D, Fan, Zhanyun, Molliex, Amandine M, Hernandez‐Vega, Amayra, Muller, Daniel, Hyman, Anthony A, Mandelkow, Eckhard, Taylor, J Paul, Hyman, Bradley T
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881631/
https://ncbi.nlm.nih.gov/pubmed/29472250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201798049
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