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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an innocuous phase of high solubility and functionality...
Kaydedildi:
| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561136/ https://ncbi.nlm.nih.gov/pubmed/28819146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00480-0 |
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