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Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Liquid–liquid phase separation (LLPS) of proteins enables the formation of non-membrane-bound organelles in cells and is associated with cancer and neurodegeneration. Little is known however about the structure and dynamics of proteins in LLPS conditions, because of the polymorphic nature of liquid-...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Ambadipudi, Susmitha, Reddy, Jithender G., Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610569/
https://ncbi.nlm.nih.gov/pubmed/31341602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00531e
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