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Structural Principles of Tau and the Paired Helical Filaments of Alzheimer’s Disease

Tau, a major microtubule‐associated protein in brain, forms abnormal fibers in Alzheimer’s disease and several other neurodegenerative diseases. Tau is highly soluble and adopts a natively unfolded structure in solution. In the paired helical filaments of Alzheimer’s disease, small segments of tau a...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Mandelkow, Eckhard, Von Bergen, Martin, Biernat, Jacek, Mandelkow, Eva‐Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095506/
https://ncbi.nlm.nih.gov/pubmed/17493042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2007.00053.x
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