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A nucleated assembly mechanism of Alzheimer paired helical filaments

Alzheimer’s disease is characterized by two types of fibrous aggregates in the affected brains, the amyloid fibers (consisting of the Aβ-peptide, generating the amyloid plaques), and paired helical filaments (PHFs; made up of tau protein, forming the neurofibrillary tangles). Hence, tau protein, a h...

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Detalhes bibliográficos
Main Authors: Friedhoff, P., von Bergen, M., Mandelkow, E.-M., Davies, P., Mandelkow, E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC28109/
https://ncbi.nlm.nih.gov/pubmed/9861035
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