Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

The microtubule-associated protein τ is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients with Alzheimer's disease (AD) and patients with several other tauopathies. Here, we show that the abnor...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Alonso, Alejandra del C., Zaidi, Tanweer, Novak, Michal, Grundke-Iqbal, Inge, Iqbal, Khalid
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11381127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121119298
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