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Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments
The microtubule-associated protein τ is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients with Alzheimer's disease (AD) and patients with several other tauopathies. Here, we show that the...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34454/ https://ncbi.nlm.nih.gov/pubmed/11381127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121119298 |
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