Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

The microtubule-associated protein τ is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients with Alzheimer's disease (AD) and patients with several other tauopathies. Here, we show that the abnor...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Alonso, Alejandra del C., Zaidi, Tanweer, Novak, Michal, Grundke-Iqbal, Inge, Iqbal, Khalid
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2001
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11381127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121119298
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