Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

The microtubule-associated protein τ is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients with Alzheimer's disease (AD) and patients with several other tauopathies. Here, we show that the abnor...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Alonso, Alejandra del C., Zaidi, Tanweer, Novak, Michal, Grundke-Iqbal, Inge, Iqbal, Khalid
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11381127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121119298
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