Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

The microtubule-associated protein τ is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (PHF) in the brains of patients with Alzheimer's disease (AD) and patients with several other tauopathies. Here, we show that the abnor...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Alonso, Alejandra del C., Zaidi, Tanweer, Novak, Michal, Grundke-Iqbal, Inge, Iqbal, Khalid
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11381127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121119298
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