Loading...

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease,...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Savastano, Adriana, Flores, David, Kadavath, Harindranath, Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839466/
https://ncbi.nlm.nih.gov/pubmed/33017094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011157
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!