Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates

Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease,...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Savastano, Adriana, Flores, David, Kadavath, Harindranath, Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7839466/
https://ncbi.nlm.nih.gov/pubmed/33017094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011157
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