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Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease,...
Shranjeno v:
| izdano v: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7839466/ https://ncbi.nlm.nih.gov/pubmed/33017094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011157 |
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