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Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
Cellular condensation of intrinsically disordered proteins (IDPs) through liquid–liquid phase separation (LLPS) allows dynamic compartmentalization and regulation of biological processes. The IDP tau, which promotes the assembly of microtubules and is hyperphosphorylated in Alzheimer's disease,...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7839466/ https://ncbi.nlm.nih.gov/pubmed/33017094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011157 |
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