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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer’s disease and several other neurodege...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Kadavath, Harindranath, Hofele, Romina V., Biernat, Jacek, Kumar, Satish, Tepper, Katharina, Urlaub, Henning, Mandelkow, Eckhard, Zweckstetter, Markus
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475932/
https://ncbi.nlm.nih.gov/pubmed/26034266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504081112
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