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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an innocuous phase of high solubility and functionality...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561136/ https://ncbi.nlm.nih.gov/pubmed/28819146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00480-0 |
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