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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
The protein Tau aggregates into tangles in the brain of patients with Alzheimer’s disease. In solution, however, Tau is intrinsically disordered, highly soluble, and binds to microtubules. It is still unclear what initiates the conversion from an innocuous phase of high solubility and functionality...
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| Wydane w: | Nat Commun |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group UK
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561136/ https://ncbi.nlm.nih.gov/pubmed/28819146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00480-0 |
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