PTPN22: the archetypal non-HLA autoimmunity gene

Por Stanford, Stephanie M., Bottini, Nunzio
Publicado no Nat Rev Rheumatol (2014)

Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

Por Stanford, Stephanie M, Rapini, Novella, Bottini, Nunzio
Publicado em 2012

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

Por Stanford, Stephanie M., Mustelin, Tomas M., Bottini, Nunzio
Publicado em 2010

Cellular Biochemistry Methods for Investigating Protein Tyrosine Phosphatases

Por Stanford, Stephanie M., Ahmed, Vanessa, Barrios, Amy M., Bottini, Nunzio
Publicado em 2014

Regulation of Lymphoid Tyrosine Phosphatase Activity: Inhibition of the Catalytic Domain by the Proximal Interdomain

Por Liu, Yingge, Stanford, Stephanie M., Jog, Sonali P., Fiorillo, Edoardo, Orrú, Valeria, Comai, Lucio, Bottini, Nunzio
Publicado em 2009

PTPN22 alters the development of T regulatory cells in the thymus

Por Maine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S., Sherman, Linda A.
Publicado em 2012

Thiuram Disulfides as Pseudo-irreversible Inhibitors of the Lymphoid Tyrosine Phosphatase

Por Kulkarni, Rhushikesh A., Stanford, Stephanie M., Vellore, Nadeem A., Krishnamurthy, Divya, Bliss, Matthew R., Baron, Riccardo, Bottini, Nunzio, Barrios, Amy M.
Publicado em 2013

Substrate Selection Influences Molecular Recognition in a Screen for Lymphoid Tyrosine Phosphatase Inhibitors

Por Kulkarni, Rhushikesh A., Vellore, Nadeem A., Bliss, Matthew R., Stanford, Stephanie M., Falk, Matthew D., Bottini, Nunzio, Baron, Riccardo, Barrios, Amy M.
Publicado em 2013

PTPome profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival

Por Stanford, Stephanie M., Maestre, Michael F., Campbell, Amanda M., Bartok, Beatrix, Kiosses, William B., Boyle, David L., Arnett, Heather A., Mustelin, Tomas, Firestein, Gary S., Bottini, Nunzio
Publicado em 2013

pCAP-Based Peptide Substrates: The New Tool in the Box of Tyrosine Phosphatase Assays

Por Stanford, Stephanie M., Krishnamurthy, Divya, Kulkarni, Rhushikesh A., Karver, Caitlin E., Bruenger, Eveline, Walker, Logan M., Ma, Chen-Ting, Chung, Thomas D. Y., Sergienko, Eduard, Bottini, Nunzio, Barrios, Amy M.
Publicado em 2013

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

Por Stanford, Stephanie M., Aleman Muench, German R., Bartok, Beatrix, Sacchetti, Cristiano, Kiosses, William B., Sharma, Jay, Maestre, Michael F., Bottini, Massimo, Mustelin, Tomas, Boyle, David L., Firestein, Gary S., Bottini, Nunzio
Publicado no Ann Rheum Dis (2014)

Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

Por Wu, Dennis J., Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M., Maine, Christian J., Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A., Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Publicado em 2014

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45

Por Stanford, Stephanie M., Panchal, Rekha G., Walker, Logan M., Wu, Dennis J., Falk, Matthew D., Mitra, Sayantan, Damle, Sagar S., Ruble, David, Kaltcheva, Teodora, Zhang, Sheng, Zhang, Zhong-Yin, Bavari, Sina, Barrios, Amy M., Bottini, Nunzio
Publicado em 2012

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

Por Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M., Liu, Yingge, Salek, Mogjiborahman, Rapini, Novella, Schenone, Aaron D., Saccucci, Patrizia, Delogu, Lucia G., Angelini, Federica, Manca Bitti, Maria Luisa, Schmedt, Christian, Chan, Andrew C., Acuto, Oreste, Bottini, Nunzio
Publicado em 2010

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Por Kiris, Erkan, Nuss, Jonathan E., Stanford, Stephanie M., Wanner, Laura M., Cazares, Lisa, Maestre, Michael F., Du, Hao T., Gomba, Glenn Y., Burnett, James C., Gussio, Rick, Bottini, Nunzio, Panchal, Rekha G., Kane, Christopher D., Tessarollo, Lino, Bavari, Sina
Publicado no PLoS One (2015)

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

Por Maeshima, Keisuke, Stanford, Stephanie M., Hammaker, Deepa, Sacchetti, Cristiano, Zeng, Li-fan, Ai, Rizi, Zhang, Vida, Boyle, David L., Aleman Muench, German R., Feng, Gen-Sheng, Whitaker, John W., Zhang, Zhong-Yin, Wang, Wei, Bottini, Nunzio, Firestein, Gary S.
Publicado no JCI Insight (2016)

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

Por Stanford, Stephanie M., Krishnamurthy, Divya, Falk, Matthew D., Messina, Rossella, Debnath, Bikash, Li, Sheng, Liu, Tong, Kazemi, Roza, Dahl, Russell, He, Yantao, Yu, Xiao, Chan, Andrew C., Zhang, Zhong-Yin, Barrios, Amy M., Woods, Virgil L., Neamati, Nouri, Bottini, Nunzio
Publicado em 2011

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice

Por Fraser, Heather I., Howlett, Sarah, Clark, Jan, Rainbow, Daniel B., Stanford, Stephanie M., Wu, Dennis J., Hsieh, Yi-Wen, Maine, Christian J., Christensen, Mikkel, Kuchroo, Vijay, Sherman, Linda A., Podolin, Patricia L., Todd, John A., Steward, Charles A., Peterson, Laurence B., Bottini, Nunzio, Wicker, Linda S.
Publicado no J Immunol (2015)

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

Por de Jong, Petrus R., Takahashi, Naoki, Harris, Alexandra R., Lee, Jihyung, Bertin, Samuel, Jeffries, James, Jung, Michael, Duong, Jen, Triano, Amy I., Lee, Jongdae, Niv, Yaron, Herdman, David S., Taniguchi, Koji, Kim, Chang-Whan, Dong, Hui, Eckmann, Lars, Stanford, Stephanie M., Bottini, Nunzio, Corr, Maripat, Raz, Eyal
Publicado em 2014

“Receptor protein tyrosine phosphatase alpha enhances rheumatoid synovial fibroblast signaling and promotes arthritis in mice”

Por Stanford, Stephanie M., Svensson, Mattias N. D., Sacchetti, Cristiano, Pilo, Caila A., Wu, Dennis J., Kiosses, William B., Hellvard, Annelie, Bergum, Brith, Aleman Muench, German R., Elly, Christian, Liu, Yun-Cai, den Hertog, Jeroen, Elson, Ari, Sap, Jan, Mydel, Piotr, Boyle, David L., Corr, Maripat, Firestein, Gary S., Bottini, Nunzio
Publicado no Arthritis Rheumatol (2016)