Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk factor for human autoimmunity. LYP is a known negative regulator of signaling through the T cell receptor (TCR), and murine Ptpn22 plays a role in thymic selection. However, the mechanism of action of...

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Detalhes bibliográficos
Main Authors: Wu, Dennis J., Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M., Maine, Christian J., Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A., Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911918/
https://ncbi.nlm.nih.gov/pubmed/24498279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086677
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