T Cells with Low Avidity for a Tissue-Restricted Antigen Routinely Evade Central and Peripheral Tolerance and Cause Autoimmunity

Por Zehn, Dietmar, Bevan, Michael J.
Publicado em 2006

Complete but curtailed T cell response to very low affinity antigen

Por Zehn, Dietmar, Lee, Sarah Y., Bevan, Michael J.
Publicado em 2009

Cutting Edge: TCR Revision Affects Predominantly Foxp3(−) Cells and Skews Them toward the Th17 Lineage

Por Zehn, Dietmar, Bevan, Michael J., Fink, Pamela J.
Publicado em 2007

Lack of Original Antigenic Sin in Recall CD8(+) T Cell Responses

Por Zehn, Dietmar, Turner, Michael J., Lefrançois, Leo, Bevan, Michael J.
Publicado em 2010

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection

Por Enouz, Sarah, Carrié, Lucie, Merkler, Doron, Bevan, Michael J., Zehn, Dietmar
Publicado em 2012

Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner

Por Zehn, Dietmar, Roepke, Sarah, Weakly, Kristin, Bevan, Michael J., Prlic, Martin
Publicado em 2013

Optimal T-cell receptor affinity for inducing autoimmunity

Por Koehli, Sabrina, Naeher, Dieter, Galati-Fournier, Virginie, Zehn, Dietmar, Palmer, Ed
Publicado no Proc Natl Acad Sci U S A (2014)

Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?

Por Viganò, Selena, Utzschneider, Daniel T., Perreau, Matthieu, Pantaleo, Giuseppe, Zehn, Dietmar, Harari, Alexandre
Publicado em 2012

T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

Por King, Carolyn G., Koehli, Sabrina, Hausmann, Barbara, Schmaler, Mathias, Zehn, Dietmar, Palmer, Ed
Publicado em 2012

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

Por Legat, Amandine, Speiser, Daniel E., Pircher, Hanspeter, Zehn, Dietmar, Fuertes Marraco, Silvia A.
Publicado em 2013

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer

Por Hebeisen, Michael, Oberle, Susanne G., Presotto, Danilo, Speiser, Daniel E., Zehn, Dietmar, Rufer, Nathalie
Publicado em 2013

Tumor-specific Ab-mediated targeting of MHC-peptide complexes induces regression of human tumor xenografts in vivo

Por Lev, Avital, Noy, Roy, Oved, Kfir, Novak, Hila, Segal, Dina, Walden, Peter, Zehn, Dietmar, Reiter, Yoram
Publicado em 2004

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

Por Keck, Simone, Schmaler, Mathias, Ganter, Stefan, Wyss, Lena, Oberle, Susanne, Huseby, Eric S., Zehn, Dietmar, King, Carolyn G.
Publicado em 2014

A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire

Por Oberle, Susanne G., Hanna-El-Daher, Layane, Chennupati, Vijaykumar, Enouz, Sarah, Scherer, Stefanie, Prlic, Martin, Zehn, Dietmar
Publicado no Cell Rep (2016)

Inhibition of mTORC2/Akt signaling to enhance the therapeutic potential of CD8 T cells

Por Zhang, Lianjun, Tschumi, Benjamin, Oberle, Susanne, Ruegg, Markus, Hall, Michael, Zehn, Dietmar, Mach, Jean-Pierre, Donda, Alena, Romero, Pedro
Publicado no J Immunother Cancer (2015)

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

Por Utzschneider, Daniel T., Alfei, Francesca, Roelli, Patrick, Barras, David, Chennupati, Vijaykumar, Darbre, Stephanie, Delorenzi, Mauro, Pinschewer, Daniel D., Zehn, Dietmar
Publicado no J Exp Med (2016)

Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner

Por Chu, Talyn, Tyznik, Aaron J., Roepke, Sarah, Berkley, Amy M., Woodward-Davis, Amanda, Pattacini, Laura, Bevan, Michael J., Zehn, Dietmar, Prlic, Martin
Publicado em 2013

pMHC affinity controls duration of CD8(+) T cell–DC interactions and imprints timing of effector differentiation versus expansion

Por Ozga, Aleksandra J., Moalli, Federica, Abe, Jun, Swoger, Jim, Sharpe, James, Zehn, Dietmar, Kreutzfeldt, Mario, Merkler, Doron, Ripoll, Jorge, Stein, Jens V.
Publicado no J Exp Med (2016)

One naive T cell, multiple fates in CD8(+) T cell differentiation

Por Gerlach, Carmen, van Heijst, Jeroen W.J., Swart, Erwin, Sie, Daoud, Armstrong, Nicola, Kerkhoven, Ron M., Zehn, Dietmar, Bevan, Michael J., Schepers, Koen, Schumacher, Ton N.M.
Publicado em 2010

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

Por Ludigs, Kristina, Jandus, Camilla, Utzschneider, Daniel T., Staehli, Francesco, Bessoles, Stéphanie, Dang, Anh Thu, Rota, Giorgia, Castro, Wilson, Zehn, Dietmar, Vivier, Eric, Held, Werner, Romero, Pedro, Guarda, Greta
Publicado no Nat Commun (2016)