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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8(+) T cells but they spare cells that react weakly to tissue-restricted antigen (TRA). To reveal the functional characteristics of these spared cells, we generated a transgenic mouse expressing the TCR of a TRA-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457731/ https://ncbi.nlm.nih.gov/pubmed/22987800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120905 |
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